Research in Life and Earth Sciences extends across three areas: biodiversity dynamics, including specifically the Moorea marine research facility (French Polynesia), which is part of a network of observatories dedicated to studying the evolution of coral reefs; cellular environment and regulation (oncogenetics, cancer pathologies and therapy); neurosciences (human and artificial cognitions, neurogenetics, neuropsychology and neuroanatomy of the human memory, pathogenesis of neurodegenerative diseases).
The Historical and Philological Sciences and the Religious Sciences sections collaborate in a number of areas: Mediterranean and Near Eastern Antiquity, history of art and archaeology, Islamic studies, Asian studies, linguistics and rare languages, medieval studies, and modern and contemporary history. In SHP, focus is given to the history of writing: Egyptian, Cuneiform, Latin, Greek, papyrology, Aramaic, and Syriac. In the Religious Sciences, emphasis is placed on the major ancient religions and the three monotheistic faiths, and also includes anthropological field study.
In digital humanities, the EPHE conducts approximately forty projects, on Antiquity, the Middle Ages, the Far-East, linguistics and history of art.